Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

Narender R. Gavva, James Treanor, András Garami, +18

Pain

InflammationMolecular PharmacologyTrpv1 BlockadeSelective Trpv1 AntagonistHyperthermia +13

The Vanilloid Receptor TRPV1 Is Tonically Activated <i>In Vivo</i> and Involved in Body Temperature Regulation

Narender R. Gavva, Anthony W. Bannon, Sekhar Surapaneni, +17

Journal of Neuroscience

The Co‐Crystal Approach to Improve the Exposure of a Water‐Insoluble Compound: AMG 517 Sorbic Acid Co‐Crystal Characterization and Pharmacokinetics

Annette Bak, Anu Gore, Evelyn Yanez, +11

Journal of Pharmaceutical Sciences

Co‐crystal ApproachPharmaceutical ScienceChemical MeasurementWater‐insoluble CompoundMedicine +5

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Erin F. DiMauro, John Newcomb, Joseph J. Nunes, +38

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyImmunologic MechanismPharmacotherapyImmunotherapeutics +18

Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-<i>a</i>]benzimidazol-5(6<i>H</i>)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes, +28

Journal of Medicinal Chemistry

Drug TargetImmunologyLymphocyte Specific KinaseNk CellsPharmaceutical Chemistry +18

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes, +42

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyImmunotherapyChemical BiologyPharmaceutical Chemistry +16

Discovery of AMG 369, a Thiazolo[5,4-<i>b</i>]pyridine Agonist of S1P₁ and S1P₅

Victor J. Cee, Mike Frohn, Brian A. Lanman, +22

ACS Medicinal Chemistry Letters

Drug TargetImmunologyAmg 369PharmacotherapyPharmaceutical Chemistry +15

Safety and Efficacy of AGN-190584 in Individuals With Presbyopia

George O. Waring, Francis W. Price, David Wirta, +7

JAMA Ophthalmology

Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation

Erin F. DiMauro, John Newcomb, Joseph J. Nunes, +32

Journal of Medicinal Chemistry

Utility of circulating tumor DNA for detection and monitoring of endometrial cancer recurrence and progression

Esther L. Moss, Diviya N. Gorsia, Anna Collins, +7

Dna AnalysisGynecologyPathologyNucleic Acid BiomarkersTumor Biology +20