S. East

ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts.

D C Blakey, P. J. Burke, D. Huw Davies et al. · PubMed · 1996 · 60 citations

Pharmacy, Oncology, Pharmacology +16

Digoxin-cyclosporine interaction: severe digitalis toxicity after cyclosporine treatment.

Paul Dorian, Carl J. Cardella, Tseela David et al. · PubMed · 1988 · 47 citations

Medicine, Pharmacokinetics, Pharmacology +17

The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing

Clifford D. Jones, David Andrews, Andrew Barker et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Engineered human carboxypeptidase B enzymes that hydrolyse hippuryl-L- glutamic acid: reversed-polarity mutants

Michael D. Edge, Clive Forder, J. Hennam et al. · Protein Engineering Design and Selection · 1998 · 32 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767

Noel R. Monks, David C. Blakey, S. East et al. · European Journal of Cancer · 2002 · 21 citations

Medicine, Cancer Biology, Oncology +13