S. East - Concepedia

Author

S. East

AstraZeneca (United Kingdom)

Also Known As

S East, S J East, S J. East, S. East, S.J. East, Simon East, Simon J. East

Publications

282

Citations

H-Index

Concepts

All Affiliations

AstraZeneca (United Kingdom)Newcastle University

About

S. East is an author at AstraZeneca (United Kingdom) specializing in medicine, pharmacology, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	204
2	Natural Sciences	2	2	45
3	Biochemistry	2	2	45
4	Engineering	1	1	32
5	Health Sciences	1	1	42

S. East

Publications

252

Citations

H-Index

Page 1

	Year	Citations
ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumor regressions in colorectal tumor xenografts. D C Blakey, P. J. Burke, D. Huw Davies, PubMed Colorectal Tumor XenograftsImmunologyPathologyImproved SystemTumor Regressions	1996	60
Digoxin-cyclosporine interaction: severe digitalis toxicity after cyclosporine treatment. Paul Dorian, Markus Strauß, Carl J. Cardella, PubMed CardiomyopathyDigoxin ToxicityCardiovascular DiseaseMedicineCardiovascular Pharmacology	1988	47
The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing Clifford D. Jones, David Andrews, Andrew Barker, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistryPharmaceutical ScienceHealth SciencesPotent Imidazole PyrimidineMedicine	2008	42
Engineered human carboxypeptidase B enzymes that hydrolyse hippuryl-L- glutamic acid: reversed-polarity mutants Michael D. Edge, Clive Forder, J. Hennam, Protein Engineering Design and Selection EngineeringMolecular BiologyHuman EnzymeEnzymatic ModificationBiosynthesis	1998	32
DNA interstrand cross-linking and TP53 status as determinants of tumour cell sensitivity in vitro to the antibody-directed enzyme prodrug therapy ZD2767 Noel R. Monks, David C. Blakey, S. East, European Journal of Cancer Tumor BiologyDna Interstrand Cross-linkingTp53 StatusTumour Cell SensitivityMedicine	2002	21
Antitumor effects of an antibody-carboxypeptidase g2 conjugate in combination with a benzoic acid mustard prodrug D C Blakey, B. Valcaccia, S. East, Cell Biophysics Medicinal ChemistryAntibody-carboxypeptidase G2 ConjugateMedicineImmunologyImmunochemistry	1993	21
Induction of apoptosis by the ADEPT agent ZD2767: comparison with the classical nitrogen mustard chlorambucil and a monofunctional ZD2767 analogue Noel R. Monks, D C Blakey, Nicola J. Curtin, British Journal of Cancer	2001	16
Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors David Andrews, Elaine S. E. Stokes, Greg Carr, Bioorganic & Medicinal Chemistry Letters Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences	2008	13

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