Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2

Allan Wissner, Heidi L. Fraser, Charles L. Ingalls, +7

Bioorganic & Medicinal Chemistry

Independent Reactive CentersDrug TargetingMedicineReceptor Tyrosine KinaseDifferent Cysteine Residues +6

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2<i>H</i>,4<i>H</i>)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2<i>H</i>,4<i>H</i>)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

Hwei‐Ru Tsou, Xiaoxiang Liu, Gary H. Birnberg, +14

Journal of Medicinal Chemistry

Organic ChemistrySelective InhibitorsHeterocycle ChemistryChemical BiologyChemical Derivative +16

4D-QSAR Analysis of a Set of Ecdysteroids and a Comparison to CoMFA Modeling

Malini Ravi, A. J. Hopfinger, Robert E. Hormann, +1

Journal of Chemical Information and Computer Sciences

Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Scott C. Mayer, A. Banker, Frank Boschelli, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineIsoquinolinedione InhibitorsLead IdentificationFibroblast Growth Factor +7

4-(Phenylaminomethylene)isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

Hwei‐Ru Tsou, Mercy Otteng, Tritin Tran, +10

Journal of Medicinal Chemistry

Chemoprevention StrategySelective InhibitorsHeterocycle ChemistryPharmaceutical ChemistryMolecular Pharmacology +14

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

Allan Wissner, M. Brawner Floyd, Bernard D. Johnson, +14

Journal of Medicinal Chemistry

Bioorganic ChemistryBoltzmann DistributionPharmacotherapyPharmaceutical ChemistryMedicinal Chemistry +15

Construction of 4D-QSAR Models for Use in the Design of Novel p38-MAPK Inhibitors

Nelilma Correia Romeiro, Magaly Girão Albuquerque, Ricardo Bicca de Alencastro, +2

Journal of Computer-Aided Molecular Design

Medicinal ChemistryNovel P38-mapk Inhibitors4D-qsar ModelsDrug TargetDrug Design +10

Structure-Based Identification of the Binding Site for the Hemiasterlin Analogue HTI-286 on Tubulin

Malini Ravi, Arie Zask, Thomas S. Rush

Biochemistry

4-Anilino-7,8-dialkoxybenzo[<i>g</i>]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

Dan M. Berger, Minu Dutia, Gary H. Birnberg, +8

Journal of Medicinal Chemistry

Free-energy force-field three-dimensional quantitative structure–activity relationship analysis of a set of p38-mitogen activated protein kinase inhibitors

Nelilma Correia Romeiro, Magaly Girão Albuquerque, Ricardo Bicca de Alencastro, +2

Journal of Molecular Modeling

Drug TargetBiochemistryMedicineNatural SciencesPharmacology +7