Mercy Otteng

Discovery of 4-(Benzylaminomethylene)isoquinoline-1,3-(2<i>H</i>,4<i>H</i>)-diones and 4-[(Pyridylmethyl)aminomethylene]isoquinoline-1,3-(2<i>H</i>,4<i>H</i>)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4

Hwei‐Ru Tsou, Xiaoxiang Liu, Gary H. Birnberg et al. · Journal of Medicinal Chemistry · 2009 · 72 citations · Full text

Organic Chemistry, Selective Inhibitors, Heterocycle Chemistry +18

4-(Phenylaminomethylene)isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-diones as Potent and Selective Inhibitors of the Cyclin-Dependent Kinase 4 (CDK4)

Hwei‐Ru Tsou, Mercy Otteng, Tritin Tran et al. · Journal of Medicinal Chemistry · 2008 · 63 citations · Full text

Chemoprevention Strategy, Selective Inhibitors, Heterocycle Chemistry +16

Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model

Christoph W. Zapf, Jonathan D. Bloom, Zhong Li et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 34 citations · Full text

Mouse Xenograft Model, Tumor Biology, Medicine +7

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity

Christoph W. Zapf, Jonathan D. Bloom, Jamie L. McBean et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 21 citations · Full text

Macrocyclic Lactams, Excellent Tumor Exposure, Medicine +9