Christoph W. Zapf

Diprotected Triflylguanidines:  A New Class of Guanidinylation Reagents

Konrad Feichtinger, Christoph W. Zapf, Heather L. Sings et al. · The Journal of Organic Chemistry · 1998 · 214 citations

Natural Sciences, Chemistry, Medicinal Chemistry +5

Chemoselective Electrosynthesis Using Rapid Alternating Polarity

Yu Kawamata, Kyohei Hayashi, Ethan Carlson et al. · Journal of the American Chemical Society · 2021 · 183 citations · Full text

Natural Sciences, Chemistry, Medicinal Chemistry +13

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 145 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

A Diels–Alder Macrocyclization Enables an Efficient Asymmetric Synthesis of the Antibacterial Natural Product Abyssomicin C

Christoph W. Zapf, Bryce A. Harrison, CARMEN DRAHL et al. · Angewandte Chemie International Edition · 2005 · 112 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +10

Covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay

Christoph W. Zapf, Brian S. Gerstenberger, Xing Li et al. · Journal of Medicinal Chemistry · 2012 · 79 citations · Full text

Pharmacy, Chemical Biology, Medicinal Chemistry +17