Nissim-Claude Cohen

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette M. Wood, Jürgen Maibaum, Joseph Rahuel et al. · Biochemical and Biophysical Research Communications · 2003 · 503 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structural Modification of the P2‘ Position of 2,7-Dialkyl-Substituted 5( <i>S</i> )-Amino-4( <i>S</i> )-hydroxy-8-phenyl-octanecarboxamides:  The Discovery of Aliskiren, a Potent Nonpeptide Human Renin Inhibitor Active after Once Daily Dosing in Marmosets

Jürgen Maibaum, Stefan Stutz, Richard Göschke et al. · Journal of Medicinal Chemistry · 2007 · 95 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Novel 2,7-Dialkyl-Substituted 5(<i>S</i>)-Amino-4(<i>S</i>)-hydroxy-8-phenyl-octanecarboxamide Transition State Peptidomimetics Are Potent and Orally Active Inhibitors of Human Renin

Richard Göschke, Stefan Stutz, Vittorio Rasetti et al. · Journal of Medicinal Chemistry · 2007 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

The P1 N-isopropyl motif bearing hydroxyethylene dipeptide isostere analogues of aliskiren are in vitro potent inhibitors of the human aspartyl protease renin

Yasuchika Yamaguchi, Keith Menear, Nissim-Claude Cohen et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 23 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13