Donald Heald

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Aman P. Singh, Xirong Zheng, Xiefan Lin‐Schmidt et al. · mAbs · 2019 · 113 citations · Full text

Medicine, Oncology, Pharmacology +17

Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans

Can Liu, Vivaswath S. Ayyar, Xirong Zheng et al. · Clinical Pharmacology & Therapeutics · 2020 · 95 citations · Full text

Life Sciences, Immunology, Oncology +17

The effects of gastric pH and food on the pharmacokinetics of a new oral cephalosporin, cefpodoxime proxetil

George S. Hughes, Donald Heald, Kerry Barker et al. · Clinical Pharmacology & Therapeutics · 1989 · 91 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Irena Loryan, Vikash Sinha, Claire Mackie et al. · Pharmaceutical Research · 2014 · 90 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

From preclinical to human – prediction of oral absorption and drug–drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

Vikash K. Sinha, Jan Snoeys, Nancy Van Osselaer et al. · Biopharmaceutics & Drug Disposition · 2012 · 82 citations

Pharmacy, Pharmacokinetics, Pharmacology +17