Irena Loryan

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Irena Loryan, Andreas Reichel, Bo Feng et al. · Pharmaceutical Research · 2022 · 135 citations · Full text

The brain slice method for studying drug distribution in the CNS

Irena Loryan, Markus Fridén, Margareta Hammarlund‐Udenaes · Fluids and Barriers of the CNS · 2013 · 97 citations · Full text

Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

Irena Loryan, Vikash Sinha, Claire Mackie et al. · Pharmaceutical Research · 2014 · 89 citations

Drug Repositioning, Drug Target, Neurophysiology +11

Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia

Irena Loryan, M. Lindqvist, Inger Johansson et al. · European Journal of Clinical Pharmacology · 2011 · 78 citations

Pilot Study, Andrology, Physiology +10

In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Irena Loryan, Erik Melander, Marcus Svensson et al. · Molecular Psychiatry · 2016 · 69 citations

In-depth Neuropharmacokinetic Analysis, Neurophysiology, Neuroanatomy +14