Markus Fridén

Structure−Brain Exposure Relationships in Rat and Human Using a Novel Data Set of Unbound Drug Concentrations in Brain Interstitial and Cerebrospinal Fluids

Markus Fridén, Susanne Winiwarter, Gunilla Jerndal et al. · Journal of Medicinal Chemistry · 2009 · 224 citations

Structure−brain Exposure Relationships, Experimental Pharmacology, Unbound Brain Exposure +19

In Vitro Methods for Estimating Unbound Drug Concentrations in the Brain Interstitial and Intracellular Fluids

Markus Fridén, Anubha Gupta, Madeleine Antonsson et al. · Drug Metabolism and Disposition · 2007 · 199 citations

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods

Markus Fridén, Fredrik Bergström, Hong Wan et al. · Drug Metabolism and Disposition · 2010 · 183 citations

Development of a High-Throughput Brain Slice Method for Studying Drug Distribution in the Central Nervous System

Markus Fridén, F. Ducrozet, Brian Middleton et al. · Drug Metabolism and Disposition · 2009 · 139 citations

Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Irena Loryan, Andreas Reichel, Bo Feng et al. · Pharmaceutical Research · 2022 · 135 citations · Full text