Xirong Zheng

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Aman P. Singh, Xirong Zheng, Xiefan Lin‐Schmidt et al. · mAbs · 2019 · 113 citations · Full text

Medicine, Oncology, Pharmacology +17

Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans

Can Liu, Vivaswath S. Ayyar, Xirong Zheng et al. · Clinical Pharmacology & Therapeutics · 2020 · 95 citations · Full text

Life Sciences, Immunology, Oncology +17

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T

Aman P. Singh, Wenbo Chen, Xirong Zheng et al. · CPT Pharmacometrics & Systems Pharmacology · 2021 · 49 citations · Full text

Life Sciences, Immunology, Pharmacokinetics +17

A quantitative LC–MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

Xiabin Chen, Xirong Zheng, Kai Ding et al. · Journal of Pharmaceutical and Biomedical Analysis · 2016 · 42 citations · Full text

Pharmacy, Pharmaceutical Analysis, Pharmacology +16

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Kai Ding, Ziyuan Zhou, Shurong Hou et al. · Scientific Reports · 2018 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17