Keisha Hearn

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery

Thomas G. Davies, William E. Wixted, Joseph E. Coyle et al. · Journal of Medicinal Chemistry · 2016 · 306 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to Dual BRAF and MEK Inhibition in Melanoma Models

Tomoko Smyth, Kim H.T. Paraiso, Keisha Hearn et al. · Molecular Cancer Therapeutics · 2014 · 91 citations · Full text

Medicine, Oncology, Pharmacology +15

Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP)

Emiliano Tamanini, Ildiko M. Buck, Gianni Chessari et al. · Journal of Medicinal Chemistry · 2017 · 71 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

Christopher W. Murray, Valério Berdini, Ildiko M. Buck et al. · ACS Medicinal Chemistry Letters · 2015 · 61 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Gianni Chessari, Ian R. Hardcastle, Jong Sook Ahn et al. · Journal of Medicinal Chemistry · 2021 · 53 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12