Atsushi Muto

A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model

Takehisa Kitazawa, Tomoyuki Igawa, Zenjiro Sampei et al. · Nature Medicine · 2012 · 496 citations

Medicine, Hematology, Immunology +17

Identification and Multidimensional Optimization of an Asymmetric Bispecific IgG Antibody Mimicking the Function of Factor VIII Cofactor Activity

Zenjiro Sampei, Tomoyuki Igawa, Tetsuhiro Soeda et al. · PLoS ONE · 2013 · 325 citations · Full text

Pharmacy, Biotechnology, Medicinal Chemistry +17

Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens

Takehisa Kitazawa, Keiko Esaki, Tatsuhiko Tachibana et al. · Thrombosis and Haemostasis · 2017 · 201 citations · Full text

Pharmacy, Immunology, Molecular Biology +16

Anti-factor IXa/X bispecific antibody ACE910 prevents joint bleeds in a long-term primate model of acquired hemophilia A

Atsushi Muto, Kazutaka Yoshihashi, Minako Takeda et al. · Blood · 2014 · 93 citations · Full text

Medicine, Hematology, Immunology +10

The neuroprotective effect of a potent and selective inhibitor of type I NOS (L-MIN) in a rat model of focal cerebral ischaemia

Toshiaki Nagafuji, Masakazu Sugiyama, Atsushi Muto et al. · Neuroreport · 1995 · 55 citations

Medicine, Neuroscience, Pharmacology +17