Concepedia

Brian Metcalf

BM

Statistics

Publications

27

Citations

2.3K

H-Index

18

Active since

1985

Affiliations

Incyte (United States)(Current)

Experimental Station

Global Blood Therapeutics (United States)

Pfizer (United States)

Brian Metcalf is an author at Incyte (United States) specializing in pharmacology, drug discovery, and medicinal chemistry.

Publications per year

1985–2022

27

Publications

27

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

Jordan S. Fridman, Peggy Scherle, Robert J. Collins et al. · The Journal of Immunology · 2010 · 463 citations · Full text

, , +17

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Eddy W. Yue, Richard Sparks, Padmaja Polam et al. · ACS Medicinal Chemistry Letters · 2017 · 296 citations · Full text

, , +8

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Eddy W. Yue, Brent Douty, Brian Wayland et al. · Journal of Medicinal Chemistry · 2009 · 217 citations · Full text

, , +9

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Brian Metcalf, Chih-Yuan Chuang, Kobina Dufu et al. · ACS Medicinal Chemistry Letters · 2017 · 190 citations · Full text

, , +17

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

Phillip C.C. Liu, Xiangdong Liu, Yanlong Li et al. · Cancer Biology & Therapy · 2006 · 186 citations · Full text

, , +17

1–5 of 27