Brian Metcalf

Selective Inhibition of JAK1 and JAK2 Is Efficacious in Rodent Models of Arthritis: Preclinical Characterization of INCB028050

Jordan S. Fridman, Peggy Scherle, Robert J. Collins et al. · The Journal of Immunology · 2010 · 440 citations · Full text

Immunology, Kinase Inhibitors, Immunotherapy +21

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Eddy W. Yue, Richard Sparks, Padmaja Polam et al. · ACS Medicinal Chemistry Letters · 2017 · 290 citations · Full text

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Eddy W. Yue, Brent Douty, Brian Wayland et al. · Journal of Medicinal Chemistry · 2009 · 216 citations · Full text

Pharmacotherapy, Vivo Pharmacodynamic Activity, Pharmaceutical Chemistry +17

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

Phillip C.C. Liu, Xiangdong Liu, Yanlong Li et al. · Cancer Biology & Therapy · 2006 · 184 citations · Full text

Erbb Family Members, Breast Oncology, Molecular Biology +19

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

Brian Metcalf, Chih-Yuan Chuang, Kobina Dufu et al. · ACS Medicinal Chemistry Letters · 2017 · 183 citations · Full text