David Westaway

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Christopher Janus, Jacqueline Pearson, JoAnne McLaurin et al. · Nature · 2000 · 1.4K citations

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +10

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

JoAnne McLaurin, Meredith E. Kierstead, Mary E. Brown et al. · Nature Medicine · 2006 · 361 citations

Molecular Pharmacology, Neurodegenerative Diseases, Alzheimer's Disease +13

Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons

Wim Annaert, Lyne Lévesque, Katleen Craessaerts et al. · The Journal of Cell Biology · 1999 · 312 citations · Full text

Protein Secretion, Molecular Biology, Amyloid Precursor Protein +19

TMP21 is a presenilin complex component that modulates γ-secretase but not ɛ-secretase activity

Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt‐Ulms et al. · Nature · 2006 · 296 citations

Protein Secretion, Signal Transduction, ɛ-Secretase Activity +9

Examining the zinc binding site of the amyloid‐β peptide

Dun‐Sheng Yang, JoAnne McLaurin, Kefeng Qin et al. · European Journal of Biochemistry · 2000 · 113 citations · Full text