Concepedia

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

JoAnne McLaurin, Meredith E. Kierstead, Mary E. Brown, Cheryl A. Hawkes, Mark H. L. Lambermon, Amie L. Phinney, Audrey A. Darabie, Julian E. Cousins, J.E. French, Melissa F Lan,

Nature Medicine · 2006 · 361 citations · 30 references

Concepts

Molecular PharmacologyNeurodegenerative DiseasesAlzheimer's DiseaseCyclohexanehexol InhibitorsMedicineNeuropharmacologyDegenerative PathologyAlzheimer PhenotypeNeurologyNeuroscienceNeurodegenerationAging-associated DiseasePharmacologyMouse ModelTreatmentProtective Mechanisms

References

30

Developments of a water-maze procedure for studying spatial learning in the rat

Richard Morris · Journal of Neuroscience Methods · 1984 · 7.1K citations

Spatial Reasoning, Cognitive Science, Neural Mechanism +9

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

Rakez Kayed, Elizabeth Head, Jennifer L. Thompson et al. · Science · 2003 · 4K citations

Soluble Amyloid Oligomers, Alzheimer's Disease, Biochemistry +12

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Sylvain Lesné, Ming Teng Koh, Linda Kotilinek et al. · Nature · 2006 · 2.7K citations

Neurodegenerative Diseases, Cognitive Science, Brain Function +12

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Christopher Janus, Jacqueline Pearson, JoAnne McLaurin et al. · Nature · 2000 · 1.4K citations

Neurodegenerative Diseases, Alzheimer's Disease, Medicine +10

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

James A. R. Nicoll, David G. Wilkinson, Clive Holmes et al. · Nature Medicine · 2003 · 1.4K citations · Full text

Neurodegenerative Diseases, Human Alzheimer Disease, Alzheimer's Disease +10