Xiu Yu

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance

Ping Chen, Nathan V. Lee, Wenyue Hu et al. · Molecular Cancer Therapeutics · 2016 · 414 citations

KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients

K.S. Gajiwala, Joe C. Wu, James G. Christensen et al. · Proceedings of the National Academy of Sciences · 2009 · 380 citations · Full text

Kit Kinase Mutants, Cancer Biology, Tumor Biology +16

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance

Alexei Brooun, K.S. Gajiwala, Ya‐Li Deng et al. · Nature Communications · 2016 · 158 citations · Full text

Crystallographic Identification of a Noncompetitive Inhibitor Binding Site on the Hepatitis C Virus NS5B RNA Polymerase Enzyme

Robert A. Love, Hans E. Parge, Xiu Yu et al. · Journal of Virology · 2003 · 143 citations · Full text

Virus Structure, Crystal Structure, Viral Replication +14

Discovery of (<i>R</i>)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Hui Li, John Tatlock, Angelica Linton et al. · Journal of Medicinal Chemistry · 2009 · 118 citations · Full text

Viral Polymerase Structure, Pharmacotherapy, Antiviral Drug +16