John Tatlock

Discovery of (<i>R</i>)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Hui Li, John Tatlock, Angelica Linton et al. · Journal of Medicinal Chemistry · 2009 · 119 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

Stephanie T. Shi, Koleen J. Herlihy, Joanne P. Graham et al. · Antimicrobial Agents and Chemotherapy · 2009 · 77 citations

Life Sciences, Infectious Diseases, Microbiology +17

Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2 <i>H</i> )-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors

Pei‐Pei Kung, Eugene Rui, Simon Bergqvist et al. · Journal of Medicinal Chemistry · 2016 · 68 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

Hui Li, John Tatlock, Angelica Linton et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1<i>H</i>-pyrazol-1-yl)ethoxy]-6-methylphenyl}-<i>N</i>-(2,2-difluoropropyl)-5,7-dihydro-6<i>H</i>-pyrrolo[3,4-<i>d</i>]pyrimidine-6-carboxamide

Luke R. Zehnder, Michael J. Bennett, Jerry Meng et al. · Journal of Medicinal Chemistry · 2011 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17