Koleen J. Herlihy

Discovery of (<i>R</i>)-6-Cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-<i>a</i>]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a Potent and Orally Available Hepatitis C Virus Polymerase Inhibitor

Hui Li, John Tatlock, Angelica Linton et al. · Journal of Medicinal Chemistry · 2009 · 118 citations · Full text

Viral Polymerase Structure, Pharmacotherapy, Antiviral Drug +16

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

Stephanie T. Shi, Koleen J. Herlihy, Joanne P. Graham et al. · Antimicrobial Agents and Chemotherapy · 2009 · 75 citations · Full text

Genotype 1A, Immunology, Molecular Biology +18

Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase Inhibitors

Koleen J. Herlihy, Joanne P. Graham, Robert A. Kumpf et al. · Antimicrobial Agents and Chemotherapy · 2008 · 48 citations · Full text

Viral Rna, Molecular Virology, Biochemistry +15

In Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

Stephanie T. Shi, Koleen J. Herlihy, Joanne P. Graham et al. · Antimicrobial Agents and Chemotherapy · 2007 · 45 citations

Hcv Polymerase Inhibitors, Molecular Biology, Antiviral Drug +16

Development of a Novel Dicistronic Reporter-Selectable Hepatitis C Virus Replicon Suitable for High-Throughput Inhibitor Screening

Weidong Hao, Koleen J. Herlihy, Noelle Jie Zhang et al. · Antimicrobial Agents and Chemotherapy · 2006 · 31 citations · Full text