Todd Shearer

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Hongfeng Deng, Heather P. O’Keefe, Christopher P. Davie et al. · Journal of Medicinal Chemistry · 2012 · 149 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors

Curt D. Haffner, J. David Becherer, Eric E. Boros et al. · Journal of Medicinal Chemistry · 2015 · 136 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

Adenosine A1 receptor modulation of MMP-2 secretion by trabecular meshwork cells.

Todd Shearer, Craig E. Crosson · PubMed · 2002 · 86 citations

Life Sciences, Cell Biology, Pharmacology +16

Identification and Characterization of 4-Chloro-<i>N</i>-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a Selective and Irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) Antagonist

Barry G. Shearer, Robert W. Wiethe, Adam Ashe et al. · Journal of Medicinal Chemistry · 2010 · 79 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

Karen A. Evans, Brian Budzik, Sean Ross et al. · Journal of Medicinal Chemistry · 2009 · 75 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15