Overexpression of the α1B-adrenergic receptor causes apoptotic neurodegeneration: Multiple system atrophy

Michael J. Zuscik, Scott A. Sands, Sean Ross, +4

Nature Medicine

PhysiologyMultiple System AtrophyApoptotic NeurodegenerationCell DeathDegenerative Disease +6

Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)

Steven M. Sparks, Grace Chen, Jon L. Collins, +15

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyLipid SynthesisBiochemistryMedicineMechanism Of Action +4

Hypotension, Autonomic Failure, and Cardiac Hypertrophy in Transgenic Mice Overexpressing the α1B-Adrenergic Receptor

Michael J. Zuscik, Dan Chalothorn, David Hellard, +12

Journal of Biological Chemistry

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes

Lihong Chen, Xiaozhou Yao, Andrew Young, +11

American Journal of Physiology-Endocrinology and Metabolism

Gastrointestinal PharmacologyPathologyFatty Liver DiseaseInsulin SignalingMetabolic Syndrome +14

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea‐pig model

Xiaozhou Yao, D. L. Anderson, Sean Ross, +9

British Journal of Pharmacology

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

Karen A. Evans, Brian Budzik, Sean Ross, +20

Journal of Medicinal Chemistry

Medicinal ChemistryBiochemistryTgr5 Receptor AgonistsNatural SciencesMedicine +11

Mice expressing the α_1B‐adrenergic receptor induces a synucleinopathy with excessive tyrosine nitration but decreased phosphorylation

Robert S. Papay, Michael J. Zuscik, Sean Ross, +7

Journal of Neurochemistry

Genetic Profiling of α1-Adrenergic Receptor Subtypes by Oligonucleotide Microarrays: Coupling to Interleukin-6 Secretion but Differences in STAT3 Phosphorylation and gp-130

Pedro J. Gonzalez‐Cabrera, Robert J. Gaivin, June Yun, +5

Molecular Pharmacology

Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist

Steven M. Sparks, Christopher Aquino, Pierette Banker, +16

Bioorganic & Medicinal Chemistry Letters

Lipid SynthesisBiochemistryOmega-3 Fatty AcidMedicinePhysiology +5

Discovery of 6,7-Dihydro-5<i>H</i>-pyrrolo[2,3-<i>a</i>]pyrimidines as Orally Available G Protein-Coupled Receptor 119 Agonists

Subba R. Katamreddy, Andrew J. Carpenter, Carina Ämmälä, +21

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +11