Heather P. O’Keefe

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

Hongfeng Deng, Heather P. O’Keefe, Christopher P. Davie et al. · Journal of Medicinal Chemistry · 2012 · 147 citations · Full text

Drug Target, Complex Mixtures, Molecular Biology +21

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of <i>Mycobacterium tuberculosis</i> InhA

Lourdes Encinas, Heather P. O’Keefe, Margarete Neu et al. · Journal of Medicinal Chemistry · 2014 · 118 citations · Full text

Bioorganic Chemistry, Hit Identification, Pharmaceutical Chemistry +22

Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)

Yun Ding, Heather P. O’Keefe, Jennifer L. DeLorey et al. · ACS Medicinal Chemistry Letters · 2015 · 77 citations · Full text

Drug Target, Molecular Biology, Selective Inhibitors +19

Synthesis of cell-permeable peptide nucleic acids and characterization of their hybridization and uptake properties

Peng Zhou, Anca Dragulescu‐Andrasi, Birendra K. Bhattacharya et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 58 citations

Nucleic Acid Chemistry, Biochemistry, Natural Sciences +8

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

N.O. Concha, Jianzhong Huang, Xiaopeng Bai et al. · Journal of Medicinal Chemistry · 2016 · 36 citations · Full text

Undecaprenyl Pyrophosphate Synthase, Bacteriology, Antimicrobial Chemotherapy +16