Lourdes Encinas

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of <i>Mycobacterium tuberculosis</i> InhA

Lourdes Encinas, Heather P. O’Keefe, Margarete Neu et al. · Journal of Medicinal Chemistry · 2014 · 118 citations · Full text

Bioorganic Chemistry, Hit Identification, Pharmaceutical Chemistry +22

Antitubercular drugs for an old target: GSK693 as a promising InhA direct inhibitor

María Martínez-Hoyos, Esther Pérez‐Herrán, Gülçin Gülten et al. · EBioMedicine · 2016 · 81 citations · Full text

Design, Synthesis, and Evaluation of New Thiadiazole-Based Direct Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) for the Treatment of Tuberculosis

Roman Šink, Izidor Sosič, Matej Živec et al. · Journal of Medicinal Chemistry · 2014 · 76 citations

Combinatorial Chemistry, Competitive Inha Inhibitors, Bioorganic Chemistry +16

THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria

Jonathan A. G. Cox, Katherine A. Abrahams, Carlos Alemparte et al. · Nature Microbiology · 2016 · 68 citations · Full text

Biochemistry, Natural Sciences, Bacteriology +5

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target

Caroline Wilson, Peter C. Ray, Fabio Zuccotto et al. · Journal of Medicinal Chemistry · 2021 · 33 citations · Full text