Justin Kwan

Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

James F. Howard, Kimiaki Utsugisawa, Michael Benatar et al. · The Lancet Neurology · 2017 · 800 citations

Medicine, Pharmacology, Pharmacotherapy +6

TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

Anna‐Leigh Brown, Oscar G. Wilkins, Matthew J. Keuss et al. · Nature · 2022 · 514 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Oliver H. Tam, Nikolay V. Rozhkov, Regina Shaw et al. · Cell Reports · 2019 · 333 citations · Full text

Life Sciences, Neurology, Neuroscience +16

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

Justin Kwan, Suh Young Jeong, Peter van Gelderen et al. · PLoS ONE · 2012 · 295 citations · Full text

Medicine, Neurology, Neuroscience +13

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

Hiroshi Tsuda, Sung Min Han, Youfeng Yang et al. · Cell · 2008 · 240 citations · Full text

Life Sciences, Neurology, Neuroscience +9