Anna‐Leigh Brown

Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia

Mercedes Prudencio, Jack Humphrey, Sarah Pickles et al. · Journal of Clinical Investigation · 2020 · 244 citations · Full text

Corticobasal Degeneration, Pathology, Neurochemical Biomarkers +18

Mis-spliced transcripts generate de novo proteins in TDP-43–related ALS/FTD

Sahba Seddighi, Yue Qi, Anna‐Leigh Brown et al. · Science Translational Medicine · 2024 · 134 citations · Full text

Genetics, Splicing Variant, Cryptic Exons +16

FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention

Jack Humphrey, Nicol Birsa, Carmelo Milioto et al. · Nucleic Acids Research · 2020 · 109 citations · Full text

Finding driver mutations in cancer: Elucidating the role of background mutational processes

Anna‐Leigh Brown, Minghui Li, Alexander Goncearenco et al. · PLoS Computational Biology · 2019 · 95 citations · Full text

Engineering, Genetics, Pathology +17

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

Holly Spence, Fergal M. Waldron, Rebecca S. Saleeb et al. · Acta Neuropathologica · 2024 · 44 citations · Full text