Peng Wang

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

Peng Wang, Juan Carlos Álvarez-Pérez, Dan P. Felsenfeld et al. · Nature Medicine · 2015 · 394 citations · Full text

Signal Transduction, Signaling Pathway, Cell Regulation +7

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

Peng Wang, Esra Karaköse, Hongtao Liu et al. · Cell Metabolism · 2018 · 155 citations · Full text

Robust Replication, Signal Transduction, Signaling Pathway +8

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas

Huan Wang, Aaron Bender, Peng Wang et al. · Nature Communications · 2017 · 87 citations · Full text

Development of Kinase-Selective, Harmine-Based DYRK1A Inhibitors that Induce Pancreatic Human β-Cell Proliferation

Kunal Kumar, Peng Wang, Roberto Sánchez et al. · Journal of Medicinal Chemistry · 2018 · 76 citations · Full text

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells

Hainan Chen, Jeffrey W. Kleinberger, Karen K. Takane et al. · Diabetes · 2015 · 58 citations · Full text