Laura R. La Bonte

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Mannose-Binding Lectin-Associated Serine Protease-1 Is a Significant Contributor to Coagulation in a Murine Model of Occlusive Thrombosis

Laura R. La Bonte, Vasile I. Pavlov, Ying Siow Tan et al. · The Journal of Immunology · 2011 · 89 citations · Full text

Immunology, Pathology, Inflammation +21

Glucagon-like Peptide-1 (GLP-1), Immediately Prior to Reperfusion, Decreases Neutrophil Activation and Reduces Myocardial Infarct Size in Rodents

Betsy B. Dokken, Laura R. La Bonte, Grace Davis‐Gorman et al. · Hormone and Metabolic Research · 2011 · 73 citations

Complement inhibition reduces injury in the type 2 diabetic heart following ischemia and reperfusion

Laura R. La Bonte, Grace Davis‐Gorman, Gregory L. Stahl et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2008 · 40 citations

Immunology, Inflammation, Metabolic Syndrome +19

Design and Discovery of <i>N</i>-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

Savithri Ramurthy, Benjamin R. Taft, Robert J. Aversa et al. · Journal of Medicinal Chemistry · 2019 · 38 citations · Full text