Carolyn A. Weigelt

Involvement of DPP‐IV catalytic residues in enzyme–saxagliptin complex formation

William J. Metzler, Joseph Yanchunas, Carolyn A. Weigelt et al. · Protein Science · 2008 · 128 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118)

Young B. Kim, Lisa M. Kopcho, Mark Kirby et al. · Archives of Biochemistry and Biophysics · 2005 · 72 citations

Life Sciences, Biochemistry, Pharmacology +12

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists

James J.‐W. Duan, Zhonghui Lu, Bin Jiang et al. · ACS Medicinal Chemistry Letters · 2019 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-<i>a</i>]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors

Wei Meng, Robert Brigance, Hannguang J. Chao et al. · Journal of Medicinal Chemistry · 2010 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Optimization of Activity, Selectivity, and Liability Profiles in 5-Oxopyrrolopyridine DPP4 Inhibitors Leading to Clinical Candidate (<i>Sa</i>)-2-(3-(Aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5<i>H</i>-pyrrolo[3,4-<i>b</i>]pyridin-6(7<i>H</i>)-yl)-<i>N</i>,<i>N</i>-dimethylacetamide (BMS-767778)

Pratik Devasthale, Ying Wang, Wei Wang et al. · Journal of Medicinal Chemistry · 2013 · 45 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16