Concepedia

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118)

Young B. Kim, Lisa M. Kopcho, Mark Kirby, Lawrence G. Hamann, Carolyn A. Weigelt, William J. Metzler, Jovita Marcinkeviciene

Archives of Biochemistry and Biophysics · 2005 · 72 citations · 39 references

DOI

Concepts

References

39

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

, , +9

Enzyme structure and mechanism

D. T. Elmore · Endeavour · 1978 · 2.7K citations

, , +13

[6] Statistical analysis of enzyme kinetic data

W. W. Cleland · Methods in enzymology on CD-ROM/Methods in enzymology · 1979 · 2K citations

, , +12

Solvent suppression in fourier transform nuclear magnetic resonance

P. J. Hore · Journal of Magnetic Resonance (1969) · 1983 · 775 citations

, , +10

Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

David J. Augeri, Jeffrey A. Robl, David A. Betebenner et al. · Journal of Medicinal Chemistry · 2005 · 621 citations · Full text

, , +10