Lawrence G. Hamann

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Min Gao, Richard E. Nettles, Makonen Belema et al. · Nature · 2010 · 937 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 740 citations

Life Sciences, Biochemistry, Cell Biology +16

Discovery and Preclinical Profile of Saxagliptin (BMS-477118):  A Highly Potent, Long-Acting, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

David J. Augeri, Jeffrey A. Robl, David A. Betebenner et al. · Journal of Medicinal Chemistry · 2005 · 621 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

Ranjan Mukherjee, Peter J. Davies, Diane L. Crombie et al. · Nature · 1997 · 610 citations

Medicine, Endocrinology, Pharmacology +14

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

James Palacino, Susanne E. Swalley, Cheng Song et al. · Nature Chemical Biology · 2015 · 428 citations

Life Sciences, Molecular Biology, Molecular Genetics +12