Robert Brigance

Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes

Robert Brigance, Wei Meng, Aberra Fura et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-<i>a</i>]pyrimidine-2-carboxamides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors

Wei Meng, Robert Brigance, Hannguang J. Chao et al. · Journal of Medicinal Chemistry · 2010 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indole-1-acetic acid, a potent analgesic agent

Dominick Mobilio, Leslie G. Humber, Alan H. Katz et al. · Journal of Medicinal Chemistry · 1988 · 29 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Synthesis, SAR, and atropisomerism of imidazolopyrimidine DPP4 inhibitors

Stephen P. O’Connor, Ying Wang, Ligaya M. Simpkins et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +6

Identification of a Hydroxypyrimidinone Compound (<b>21</b>) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure

Wei Meng, Zulan Pi, Robert Brigance et al. · Journal of Medicinal Chemistry · 2021 · 13 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17