Stan Riney

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 597 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +17

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Wen Shen, Cheryl Li De Hoyos, Michael T. Migawa et al. · Nature Biotechnology · 2019 · 333 citations

Medicine, Biochemistry, Pharmacology +13

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

Xue‐hai Liang, Hong Sun, Wen Shen et al. · Nucleic Acids Research · 2017 · 137 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

An oral antisense oligonucleotide for PCSK9 inhibition

Peter Gennemark, Katrin Walter, Niclas Clemmensen et al. · Science Translational Medicine · 2021 · 121 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice

Rosie Z. Yu, Mark Graham, Noah Post et al. · Molecular Therapy — Nucleic Acids · 2016 · 92 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12