Larry G. Higgins

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

Annette MacLeod, Michael McMahon, Simon Plummer et al. · Carcinogenesis · 2009 · 292 citations · Full text

Transcription Factor Nrf2 Is Essential for Induction of NAD(P)H:Quinone Oxidoreductase 1, Glutathione S-Transferases, and Glutamate Cysteine Ligase by Broccoli Seeds and Isothiocyanates

Gail K. McWalter, Larry G. Higgins, Lesley I. McLellan et al. · Journal of Nutrition · 2004 · 212 citations · Full text

Reductive Stress, Biochemistry, Broccoli Seeds +8

Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents

Larry G. Higgins, Michael Kelleher, Ian M. Eggleston et al. · Toxicology and Applied Pharmacology · 2009 · 172 citations

Inflammation, Cytotoxic Effects, Reductive Stress +12

Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

Neil R. Kitteringham, Azman Abdullah, Joanne Walsh et al. · Journal of Proteomics · 2010 · 168 citations · Full text

Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H‐1,2‐dithiole‐3‐thione

Francesc X. Soriano, Frédéric Léveillé, Sofia Papadia et al. · Journal of Neurochemistry · 2008 · 137 citations · Full text

Hyperoxidized Peroxiredoxins, Cell Death, Redox Biology +16