Simon Plummer

Phase I Clinical Trial of Oral Curcumin

Ricky A. Sharma, Stephanie A. Euden, Sharon L. Platton et al. · Clinical Cancer Research · 2004 · 1.2K citations · Full text

Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex

Simon Plummer, Karen Holloway, Margaret M. Manson et al. · Oncogene · 1999 · 632 citations

Inflammation, Anti-inflammatory, Chemoprevention Strategy +12

Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production.

Christopher R. Ireson, S Orr, Donald J. L. Jones et al. · PubMed · 2001 · 591 citations

Chemoprevention Strategy, Nutraceutical Ingredient, Pathology +19

Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the BACH1–NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds

Annette MacLeod, Michael McMahon, Simon Plummer et al. · Carcinogenesis · 2009 · 292 citations · Full text

Human Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR) Support the Hypertrophic but not the Hyperplastic Response to the Murine Nongenotoxic Hepatocarcinogens Phenobarbital and Chlordane In Vivo

Jillian Ross, Simon Plummer, Anja Rode et al. · Toxicological Sciences · 2010 · 150 citations

Double Knockout Pxr, Chemoprevention Strategy, Pathology +16