Lesley I. McLellan

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · PubMed · 2001 · 656 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

Simon A. Chanas, Qingwu Jiang, Michael McMahon et al. · Biochemical Journal · 2002 · 448 citations · Full text

Pharmacy, Genetics, Toxicology +17

Transcription Factor Nrf2 Is Essential for Induction of NAD(P)H:Quinone Oxidoreductase 1, Glutathione S-Transferases, and Glutamate Cysteine Ligase by Broccoli Seeds and Isothiocyanates

Gail K. McWalter, Larry G. Higgins, Lesley I. McLellan et al. · Journal of Nutrition · 2004 · 213 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Glutathione and glutathione-dependent enzymes in cancer drug resistance

Lesley I. McLellan, C. Roland Wolf · Drug Resistance Updates · 1999 · 129 citations

Medicine, Biochemistry, Oncology +14

Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype

Tim W. P. Devling, Christopher Lindsay, Lesley I. McLellan et al. · Proceedings of the National Academy of Sciences · 2005 · 119 citations · Full text

Medicine, Molecular Biology, Oncology +14