Crystal L. Mackall

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson et al. · The Lancet · 2014 · 2.9K citations

T Cells, T-regulatory Cell, Immunology +9

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern et al. · Nature Medicine · 2015 · 1.7K citations · Full text

Autoimmune Disease, Tonic Signaling, Immunology +12

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

Paul F. Robbins, Richard A. Morgan, Steven A. Feldman et al. · Journal of Clinical Oncology · 2011 · 1.6K citations · Full text

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry, Nirali N. Shah, Rimas J. Orentas et al. · Nature Medicine · 2017 · 1.3K citations · Full text

Allergy, Autoimmune Disease, Cd19-targeted Car Immunotherapy +9

c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn, Evan W. Weber, Elena Sotillo et al. · Nature · 2019 · 831 citations · Full text

Physiology, Autoimmunity, Tolerance Induction +6