c-Jun overexpression in CAR T cells induces exhaustion resistance

Rachel C. Lynn, Evan W. Weber, Elena Sotillo, +16

Nature

PhysiologyAutoimmunityTolerance InductionImmunotherapyMedicine +4

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

Evan W. Weber, Kevin R. Parker, Elena Sotillo, +23

Science

Tuning the Antigen Density Requirement for CAR T-cell Activity

Robbie G. Majzner, Skyler P. Rietberg, Elena Sotillo, +17

Cancer Discovery

CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial

Jay Y. Spiegel, Shabnum Patel, Lori Muffly, +46

Nature Medicine

A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor

Katarzyna Urbańska, Evripidis Lanitis, Mathilde Poussin, +6

Cancer Research

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Alba Rodríguez-García, Rachel C. Lynn, Mathilde Poussin, +8

Nature Communications

Pharmacologic control of CAR-T cell function using dasatinib

Evan W. Weber, Rachel C. Lynn, Elena Sotillo, +3

Blood Advances

Cell TherapySafety SwitchCar-t Cell FunctionImmunologyImmune Checkpoint Inhibitor +10

Targeting of folate receptor β on acute myeloid leukemia blasts with chimeric antigen receptor–expressing T cells

Rachel C. Lynn, Mathilde Poussin, Anna Kalota, +4

Blood

Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines

Edmund K. Moon, Liang‐Chuan S. Wang, Kheng Bekdache, +4

OncoImmunology

ImmunologyT CellsImmunotherapyTumor ImmunologyIntra-tumoral Delivery +15

High-affinity FRβ-specific CAR T cells eradicate AML and normal myeloid lineage without HSC toxicity

Rachel C. Lynn, Yang Feng, Keith Schutsky, +4

Leukemia

Hsc ToxicityHematologyImmunologyNormal Myeloid LineageT Cell Immunity +6