W. Howard Roark

Discovery and Characterization of a Novel Inhibitor of Matrix Metalloprotease-13 That Reduces Cartilage Damage in Vivo without Joint Fibroplasia Side Effects

Adam R. Johnson, A.G. Pavlovsky, Daniel F. Ortwine et al. · Journal of Biological Chemistry · 2007 · 211 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

James S. Kaltenbronn, James P. Hudspeth, E. A. Lunney et al. · Journal of Medicinal Chemistry · 1990 · 74 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis of a chiral synthon for the lactone portion of compactin and mevinolin

Bruce D. Roth, W. Howard Roark · Tetrahedron Letters · 1988 · 72 citations

Natural Sciences, Chemistry, Medicinal Chemistry +8

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

Bruce D. Roth, C. John Blankley, M. L. HOEFLE et al. · Journal of Medicinal Chemistry · 1992 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Inhibitors of acyl-CoA:cholesterol acyltransferase. 4. A novel series of urea ACAT inhibitors as potential hypocholesterolemic agents

Bharat K. Trivedi, Ann Holmes, Terri L. Stoeber et al. · Journal of Medicinal Chemistry · 1993 · 55 citations · Full text

Life Sciences, Biochemistry, Pharmacology +14