M. L. HOEFLE - Concepedia

Author

M. L. HOEFLE

Warde Medical Laboratory

Also Known As

M. HOEFLE, M. Hoefle, M. L. HOEFLE, M. L. Hoefle, Milton Hoefle, Milton L. Hoefle

Publications

771

Citations

H-Index

Concepts

All Affiliations

Warde Medical Laboratory Pfizer (United States)

About

M. L. HOEFLE is an author at Warde Medical Laboratory specializing in pharmacology, drug discovery, and medicinal chemistry.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	8	8	366
2	Natural Sciences	7	7	310
3	Biochemistry	7	7	258
4	Chemical Biology	4	4	254
5	Engineering	1	1	10

M. L. HOEFLE

Publications

747

Citations

H-Index

Page 1

	Year	Citations
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus Bruce D. Roth, C. John Blankley, Alexander Chucholowski, Journal of Medicinal Chemistry	1991	183
Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types S. KLUTCHKO, C. John Blankley, Robert W. Fleming, Journal of Medicinal Chemistry Vitro PotencyPharmaceutical ScienceEnzyme Inhibitor QuinaprilPharmacotherapyChemical Biology	1986	82
Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus Bruce D. Roth, Daniel F. Ortwine, M. L. HOEFLE, Journal of Medicinal Chemistry	1990	70
Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents Bruce D. Roth, C. John Blankley, M. L. HOEFLE, Journal of Medicinal Chemistry Chemical BiologyPharmaceutical ChemistryMedicinal ChemistryFatty Acid AnilidesPharmacological Study	1992	67
Pyrimido [4,5-d]pyrimidines. Part I Edward C. Taylor, Robert J. Knopf, Robert Meyer, Journal of the American Chemical Society Combinatorial ChemistryMedicinal ChemistryMolecular SciencesBioorganic ChemistryChemical Analysis	1960	64
Inhibitors of cholesterol biosynthesis. 2. 1,3,5-Trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles Drago R. Sliskovic, Bruce D. Roth, Marina Wilson, Journal of Medicinal Chemistry	1990	63
Cardioselective .beta.-adrenergic blocking agents. 1. 1-[(3,4-Dimethoxyphenethyl)amino]-3-aryloxy-2-propanols M. L. HOEFLE, S. G. Hastings, Robert Meyer, Journal of Medicinal Chemistry Combinatorial ChemistryMolecular PharmacologyMedicinal ChemistryCardioselective Beta-blockadeOptimal Potency	1975	54
Derivatives of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline: effect of changes at postions 2 and 5 of the hexanoic acid portion Ronald G. Almquist, Jac Crase, Clive Jennings-White, Journal of Medicinal Chemistry HypertensionPharmacotherapyChemical BiologyPharmaceutical ChemistryBlood Pressure	1982	41
Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogs: potent angiotensin converting enzyme inhibitors Robert Meyer, Ernest D. Nicolaides, Francis G. Tinney, Journal of Medicinal Chemistry	1981	38
Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(mercaptomethyl)-2-oxo-1-piperidineacetic acids S. KLUTCHKO, M. L. HOEFLE, Ronald D. Smith, Journal of Medicinal Chemistry Combinatorial ChemistryMolecular PharmacologyMedicinal ChemistryInhibitory ActivityBioorganic Chemistry	1981	35

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