M. L. HOEFLE

Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus

Bruce D. Roth, C. John Blankley, Alexander Chucholowski et al. · Journal of Medicinal Chemistry · 1991 · 183 citations · Full text

Life Sciences, Biochemistry, Pharmacology +13

Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity relationships for non-sulfhydryl and sulfhydryl types

S. KLUTCHKO, C. John Blankley, Robert W. Fleming et al. · Journal of Medicinal Chemistry · 1986 · 83 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

Bruce D. Roth, Daniel F. Ortwine, M. L. HOEFLE et al. · Journal of Medicinal Chemistry · 1990 · 70 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +14

Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents

Bruce D. Roth, C. John Blankley, M. L. HOEFLE et al. · Journal of Medicinal Chemistry · 1992 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Pyrimido [4,5-d]pyrimidines. Part I

Edward C. Taylor, Robert J. Knopf, Robert Meyer et al. · Journal of the American Chemical Society · 1960 · 66 citations

Pharmacy, Chemistry, Medicinal Chemistry +9