Yen-Der Li

The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold et al. · Nature · 2020 · 389 citations · Full text

Protein Function, Signal Transduction, Cell Regulation +10

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Jonathan M. Tsai, Jacob D. Aguirre, Yen-Der Li et al. · Molecular Cell · 2023 · 66 citations · Full text

Molecular Regulation, Retinoic Acid, Molecular Biology +18

Template-assisted covalent modification underlies activity of covalent molecular glues

Yen-Der Li, W Michelle, Muhammad Murtaza Hassan et al. · Nature Chemical Biology · 2024 · 64 citations · Full text

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Roman C. Sarott, Inchul You, Yen-Der Li et al. · Journal of the American Chemical Society · 2023 · 57 citations

Aldo-keto Reductase, Protein Assembly, Molecular Biology +17

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Mingxing Teng, Wenchao Lu, Katherine A. Donovan et al. · Journal of Medicinal Chemistry · 2021 · 50 citations · Full text