The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, +21

Nature

Protein FunctionSignal TransductionCell RegulationNatural SciencesCdk Inhibitor Cr8 +8

UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability

Jonathan M. Tsai, Jacob D. Aguirre, Yen-Der Li, +32

Molecular Cell

Molecular RegulationRetinoic AcidMolecular BiologyNuclear Hormone ReceptorsTranscriptional Regulation +16

Template-assisted covalent modification underlies activity of covalent molecular glues

Yen-Der Li, W Michelle, Muhammad Murtaza Hassan, +32

Nature Chemical Biology

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry

Roman C. Sarott, Inchul You, Yen-Der Li, +13

Journal of the American Chemical Society

Aldo-keto ReductaseProtein AssemblyMolecular BiologyChemical BiologyRedox Biology +15

Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216

Mingxing Teng, Wenchao Lu, Katherine A. Donovan, +9

Journal of Medicinal Chemistry

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

Yen-Der Li, W Michelle, Muhammad Murtaza Hassan, +25

PD-1 blockade synergizes with intratumoral vaccination of a therapeutic HPV protein vaccine and elicits regression of tumor in a preclinical model

Shiwen Peng, Marietta Tan, Yen-Der Li, +7

Cancer Immunology Immunotherapy

VaccinationTumor ImmunologyPd-1 BlockadeVaccine TargetPreclinical Model +8

Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues

Muhammad Murtaza Hassan, Yen-Der Li, W Michelle, +16

European Journal of Medicinal Chemistry

How SARS-CoV-2 Transformed the Clinical Laboratory: Challenges and Lessons Learned

Jonathan M. Tsai, Nicole V. Tolan, Athena K. Petrides, +7

The Journal of Applied Laboratory Medicine

Point-of-care TestingHealth InformaticsViral DiagnosticsDiagnostic TestCovid-19 Pandemic +11

Chemical-free inactivated whole influenza virus vaccine prepared by ultrashort pulsed laser treatment

Shaw-Wei D Tsen, Nisha Donthi, Victor La, +8

Journal of Biomedical Optics