Wenchao Lu

Discovery and resistance mechanism of a selective CDK12 degrader

Baishan Jiang, Yang Gao, Jianwei Che et al. · Nature Chemical Biology · 2021 · 131 citations · Full text

Signal Transduction, Natural Sciences, Receptor Tyrosine Kinase +5

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Suman Mukhopadhyay, Hsin‐Yi Huang, Ziyan Lin et al. · Cancer Research · 2023 · 94 citations · Full text

Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors

Wenchao Lu, Jun Wang, Yong Li et al. · European Journal of Medicinal Chemistry · 2019 · 86 citations · Full text

Biochemistry, Polymer-drug Conjugate, Medicine +6

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling

Mengyang Fan, Wenchao Lu, Jianwei Che et al. · eLife · 2022 · 61 citations · Full text

Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins

Deheng Chen, Tian Lu, Ziqin Yan et al. · European Journal of Medicinal Chemistry · 2019 · 56 citations · Full text

Protein Chemistry, Medicinal Chemistry, Protein Function +8