Concepedia

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Suman Mukhopadhyay, Hsin‐Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu, Y. Liu, Yi Ban, Kayla Guidry, Hai Hu,

Cancer Research · 2023 · 94 citations · 58 references

DOIFull text

Open access

Abstract

Identification of synthetic lethal genes with KRASG12C using genome-wide CRISPR/Cas9 screening and credentialing of the ability of TEAD inhibition to enhance KRASG12C efficacy provides a roadmap for combination strategies. See related commentary by Johnson and Haigis, p. 4005.

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