The bone marrow microenvironment at single-cell resolution

Anastasia N. Tikhonova, Igor Dolgalev, Hai Hu, +22

Nature

MedicineBiological MicroenvironmentsSingle-cell AnalysisCell BiologyBone Marrow Microenvironment

CXCL12-Producing Vascular Endothelial Niches Control Acute T Cell Leukemia Maintenance

Lauren A. Pitt, Anastasia N. Tikhonova, Hai Hu, +11

Cancer Cell

ImmunologyCellular Immune ResponseAdult T-cell Leukemia-lymphomaMedicineCell Biology +1

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Andreas Kloetgen, Palaniraja Thandapani, Panagiotis Ntziachristos, +17

Nature Genetics

ChromatinMixed-phenotype Acute LeukemiaNuclear OrganizationAdult T-cell Leukemia-lymphomaMedicine +3

<i>In Vivo</i> Epigenetic CRISPR Screen Identifies <i>Asf1a</i> as an Immunotherapeutic Target in <i>Kras</i> -Mutant Lung Adenocarcinoma

Fei Li, Qingyuan Huang, Troy A. Luster, +25

Cancer Discovery

Direct migration of follicular melanocyte stem cells to the epidermis after wounding or UVB irradiation is dependent on Mc1r signaling

Wei Chin Chou, Makoto Takeo, Piul S. Rabbani, +6

Nature Medicine

Developmental BiologyUvb IrradiationMedicinePhotocarcinogenesisMelanoma +10

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer

Jiehui Deng, Aatish Thennavan, Igor Dolgalev, +35

Nature Cancer

MedicineImmunologyTumor ImmunityUlk1 Inhibition OvercomesAntigen Presentation +7

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Suman Mukhopadhyay, Hsin‐Yi Huang, Ziyan Lin, +23

Cancer Research

Dedifferentiation maintains melanocyte stem cells in a dynamic niche

Qi Sun, Wendy Lee, Hai Hu, +10

Nature

Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia

Nikos Kourtis, Charalampos Lazaris, Kathryn Hockemeyer, +16

Nature Medicine

Hematological MalignancyStress Response MachineryMedicineMixed-phenotype Acute LeukemiaMalignant Blood Disorder +8

EdnrB Governs Regenerative Response of Melanocyte Stem Cells by Crosstalk with Wnt Signaling

Makoto Takeo, Wendy Lee, Piul S. Rabbani, +5

Cell Reports