limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu, +4

Nucleic Acids Research

GeneticsMolecular BiologyTranscriptomics TechnologyLimma PackageGenomics +17

Features and development of <i>Coot</i>

Paul Emsley, Bernhard Lohkamp, W. G. Scott, +1

Acta Crystallographica Section D Biological Crystallography

SyntaxModel ValidationEngineeringVisual Programming LanguageMedicine +13

<i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams, Pavel V. Afonine, G. Bunkóczi, +15

Acta Crystallographica Section D Biological Crystallography

X-ray CrystallographyStructural BioinformaticsBiomolecular Structure PredictionNatural SciencesMedicine +12

Inference of Macromolecular Assemblies from Crystalline State

Evgeny Krissinel, Kim Henrick

Journal of Molecular Biology

Crystal StructureMacromolecular SystemCrystalline StateMacromolecular ArchitectureCrystallography +2

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani, John L. Rubinstein, David J. Fleet, +1

Nature Methods

EngineeringPhysicsStructural BioinformaticsCryogenicsStructure Determination +4

<i>REFMAC</i>5 for the refinement of macromolecular crystal structures

Garib N. Murshudov, Pavol Skubák, Andrey A. Lebedev, +5

Acta Crystallographica Section D Biological Crystallography

Crystal StructureEngineeringCcp4 SuiteBiophysicsAnisotropic Adps +12

UCSF ChimeraX: Meeting modern challenges in visualization and analysis

Thomas D. Goddard, Conrad C. Huang, Elaine C. Meng, +4

Protein Science

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

John G. Doench, Nicolò Fusi, Meagan E. Sullender, +10

Nature Biotechnology

Systems BiologyOff-target EffectNatural SciencesMolecular BiologySgrna Design +8

Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud, +22

Nature

Bet BromodomainsGeneticsPathogenesisMolecular GeneticsMedicine +1

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

Eugene Krissinel, K. Henrick

Acta Crystallographica Section D Biological Crystallography