An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo

Brandon J. Aubrey, Gemma L. Kelly, Andrew J. Kueh, +7

Cell Reports

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

Lorraine A. O’ Reilly, Lin Tai, Lily Lee, +11

Nature

Proteinlipid InteractionMembrane-bound Fas LigandSignal TransductionBiochemistryNatural Sciences +7

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

Thomas Kaufmann, Lin Tai, Paul G. Ekert, +6

Cell

Genome InstabilityProtein FunctionNatural SciencesApoptosisMolecular Biology +7

DNA repair processes are critical mediators of p53-dependent tumor suppression

Ana Janic, Liz J. Valente, Matthew J. Wakefield, +15

Nature Medicine

Tumor BiologyGenome InstabilityDna Repair ProcessesDna DamageCell Regulation +8

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in <i>p53</i>

Gemma L. Kelly, Stephanie Grabow, Stefan Glaser, +16

Genes & Development

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis

Ewa M. Michalak, Elisa S. Jansen, Lina Happo, +6

Cell Death and Differentiation

Tumor BiologyLymphoid NeoplasiaOncogenic AgentMedicineImmunology +7

Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection

Marcel Doerflinger, Yexuan Deng, Paul G. Whitney, +25

Immunity

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Rachel Thijssen, Sarah T. Diepstraten, Donia M. Moujalled, +33

Blood

BCL-2 family member BOK is widely expressed but its loss has only minimal impact in mice

Francine Ke, Anne K. Voss, J. B. Kerr, +6

Cell Death and Differentiation

Knockout MouseMolecular PhysiologySignal TransductionSignaling PathwayCell Regulation +8

Humanized Mcl-1 mice enable accurate preclinical evaluation of MCL-1 inhibitors destined for clinical use

Margs S. Brennan, Catherine Chang, Lin Tai, +5

Blood