Paolo Schiavini

Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists

James O’Brien-Brown, Alexander Jackson, Tristan A. Reekie et al. · European Journal of Medicinal Chemistry · 2017 · 32 citations · Full text

Novel Series, Biochemistry, Functional Selectivity +7

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold

Michael G. Brant, Jake Goodwin‐Tindall, Kurt R. Stover et al. · ACS Medicinal Chemistry Letters · 2018 · 32 citations · Full text

3-Oxo-hexahydro-1<i>H</i>-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors

Gaëlle Mariaule, Stéphane De Cesco, Francesco Airaghi et al. · Journal of Medicinal Chemistry · 2015 · 25 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Conformationally Constrained Covalent +14

Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands

Samuel D. Banister, Iman A. Moussa, Corinne Beinat et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 19 citations · Full text

Functional Selectivity, Selective Dopamine Transporter, Medicine +8

Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity

Paolo Schiavini, Kin Jack Cheong, Nicolas Moitessier et al. · ChemBioChem · 2016 · 14 citations

Active Site Crowding, Molecular Biology, Large Active Site +17