James O’Brien-Brown

The P2X7 receptor tracer [11C]SMW139 as an in vivo marker of neuroinflammation in multiple sclerosis: a first-in man study

Marloes Hagens, Sandeep S.V. Golla, Bieneke Janssen et al. · European Journal of Nuclear Medicine and Molecular Imaging · 2019 · 75 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X₇ Receptor Antagonist

Shane M. Wilkinson, Melissa L. Barron, James O’Brien-Brown et al. · ACS Chemical Neuroscience · 2017 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists

James O’Brien-Brown, Alexander Jackson, Tristan A. Reekie et al. · European Journal of Medicinal Chemistry · 2017 · 32 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

PET imaging of P2X7R in the experimental autoimmune encephalomyelitis model of multiple sclerosis using [11C]SMW139

Wissam Beaino, Bieneke Janssen, Esther Kooijman et al. · Journal of Neuroinflammation · 2020 · 28 citations · Full text

Life Sciences, Neurology, Neuroscience +16

The novel P2X7 receptor antagonist PKT100 improves cardiac function and survival in pulmonary hypertension by direct targeting of the right ventricle

Thomas Hansen, Keyvan Karimi Galougahi, Marie Besnier et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2020 · 17 citations

Medicine, Cardiology, Pharmacology +15