Concepedia

Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists

James O’Brien-Brown, Alexander Jackson, Tristan A. Reekie, Melissa L. Barron, Eryn L. Werry, Paolo Schiavini, Michelle N. McDonnell, Lenka Munoz, Shane M. Wilkinson, Benjamin Noll,

European Journal of Medicinal Chemistry · 2017 · 32 citations · 21 references

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21

Behavioral despair in mice: a primary screening test for antidepressants.

Porsolt Rd, Aurélie Bertin, M Jalfre · PubMed · 1977 · 3.3K citations

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Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice

Vincent Castagné, Paul Moser, Sylvain Roux et al. · Current Protocols in Neuroscience · 2011 · 690 citations

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P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

Lav K. Parvathenani, Svetlana Tertyshnikova, Corinne Greco et al. · Journal of Biological Chemistry · 2003 · 481 citations · Full text

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A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Prisca Honoré, Diana L. Donnelly‐Roberts, Marian T. Namovic et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 409 citations

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Clinical evaluation of the efficacy of the P2X7 purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

Edward Keystone, Millie M Wang, Mark Layton et al. · Annals of the Rheumatic Diseases · 2012 · 310 citations

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