A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

Lenka Munoz, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, +6

Journal of Neuroinflammation

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Hänggi, Gabriela Brumatti, +27

Cancer Cell

Mk2 EnhancesDrug TargetingMedicineMechanism Of ActionAnti-cancer Agent +5

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells

Yiu To Yeung, Nicole S. Bryce, Seray Adams, +7

Journal of Neuro-Oncology

Neuro-oncologyP38 Mapk InhibitorsGliomaReceptor Tyrosine KinaseImmunology +6

The p38-MK2-HuR pathway potentiates EGFRvIII–IL-1β-driven IL-6 secretion in glioblastoma cells

Fadi Gurgis, Yiu To Yeung, Minying Tang, +8

Oncogene

Signaling PathwayCell RegulationGliomaMedicineImmunology +7

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits

Wenhui Hu, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, +6

Bioorganic & Medicinal Chemistry Letters

Synaptic PlasticityNovel Therapeutic SuppressorNeurophysiologyMedicineNeuropharmacology +10

Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma

Qingqing Zhou, Athena Phoa, Ramzi H. Abbassi, +9

Journal of Medicinal Chemistry

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Ariadna Recasens, Sean J. Humphrey, M. A. Ellis, +11

Cell Death Discovery

Novel p38 MAPK inhibitor ML3403 has potent anti-inflammatory activity in airway smooth muscle

Lenka Munoz, Emma E. Ramsay, Melanie Manetsch, +4

European Journal of Pharmacology

InflammationMolecular PharmacologyAnti-inflammatoryMolecular PhysiologyInflammatory Lung Disease +10

Optimisation of LRRK2 inhibitors and assessment of functional efficacy in cell-based models of neuroinflammation

Lenka Munoz, Madeline E. Kavanagh, Athena Phoa, +6

European Journal of Medicinal Chemistry

Cell-based ModelsSignal TransductionLrrk2 InhibitorsMedicineReceptor Tyrosine Kinase +9

Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent

Alexander Döbber, Athena Phoa, Ramzi H. Abbassi, +6

ACS Medicinal Chemistry Letters

PhotobiologyPharmaceutical ChemistryNanomedicineMolecular PharmacologyMedicinal Chemistry +17