A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

Lenka Munoz, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, +6

Journal of Neuroinflammation

Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation

Wenmin Deng, Zhongjin Yang, Yue Hu, +3

Free Radical Biology and Medicine

InflammationRheumatologyAnti-inflammatoryAutoimmune DiseaseImmunology +9

Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits

Wenhui Hu, Hantamalala Ralay Ranaivo, Saktimayee M. Roy, +6

Bioorganic & Medicinal Chemistry Letters

Synaptic PlasticityNovel Therapeutic SuppressorNeurophysiologyMedicineNeuropharmacology +10

Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors

Xin Zhao, Yanling Jie, Matthew Rosenberg, +8

Antiviral Research

Medicinal ChemistryMedicineAntiviral Drug DevelopmentPharmacologyAntiviral Compound +2

The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes

Jifeng Deng, Li Peng, Guicheng Zhang, +11

European Journal of Medicinal Chemistry

BiochemistryMedicineNatural SciencesDiabetesPeptoid +8

Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus

Jianghong Dong, Shengwei Chen, Runfeng Li, +5

European Journal of Medicinal Chemistry

BiochemistryImidazole-based Pinanamine DerivativesDual InhibitorsDrug DiscoveryMedicine +7

Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library

Wenhui Hu, Shaogao Zeng, Chufang Li, +3

Journal of Medicinal Chemistry

Matrix-2 Protein InhibitorsDrug TargetHit IdentificationMolecular BiologyAntiviral Drug +17

Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation

Yue Hu, Zhongjin Yang, Yitao Ou, +7

International Immunopharmacology

InflammationAnti-inflammatoryMitochondrial DamageAutoimmune DiseaseLipid Peroxidation +10

Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization

Hui Xie, Lili Zeng, Shaogao Zeng, +12

European Journal of Medicinal Chemistry

BiochemistryNovel Pyrrolopyrimidine AnaloguesMedicineRational Drug DesignPharmacological Agent +6

P4–428: Glia as a therapeutic target: Selective suppression of human amyloid–beta–induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration

Linda J. Van Eldik, Hantamalala Ralay Ranaivo, Wenhui Hu, +4

Alzheimer s & Dementia

Glial BiologyActivated GliaSelective SuppressionCell DeathNeurochemical Biomarkers +22