Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

Pharmacy, Pharmacokinetics, Pharmacology +15

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

Mark C. Wenlock, Rupert P. Austin, Patrick Barton et al. · Journal of Medicinal Chemistry · 2003 · 537 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Head injury and the risk of AD in the MIRAGE study

Zixuan Guo, L. Adrienne Cupples, Alexander Kurz et al. · Neurology · 2000 · 508 citations

Medicine, Genetics, Neurology +16

Characteristic Physical Properties and Structural Fragments of Marketed Oral Drugs

Michal Vieth, Miles G. Siegel, Richard E. Higgs et al. · Journal of Medicinal Chemistry · 2003 · 356 citations

Pharmacy, Pharmacokinetics, Pharmacology +14